Out with the Old, In with the New: A Review of the Treatment of Intrapartum Infections.

Purpose of Review: In 2019, a global meta-analysis demonstrated incidence of 3.9% for chorioamnionitis, 1.6% for endometritis, 1.2% for wound infection, 0.05% for sepsis, and 1.1% for maternal peripartum infection (Woodd et al. in PLOS Med 16(12):e1002984, 2019). Antimicrobial regimens for these infections are based on older microbiology profiles and may not account for changes in antimicrobial susceptibility data or the availability more modern antimicrobial therapies. Recent Findings: Recommendations for treatment of puerperal infection have not changed significantly in recent decades, despite the availability of new antimicrobial therapies with improved safety profiles. Summary: A consideration should be given to monotherapy or two-drug regimens that have fewer toxicities than older therapeutics and require less monitoring. Obtaining appropriate microbiologic data and antimicrobial susceptibility data is critical to balance broad-spectrum coverage with the threat of antimicrobial resistance. [ABSTRACT FROM AUTHOR]