The Effect And Safety Of Minimally Invasive Surgery Combined With Naoxueshu Oral Liquid On Spontaneous Cerebral Hemorrhage: Meta-Analysis And Quality Evaluation.

Objective:To systematically evaluate the efficacy and safety of minimally invasive removal of intracranial hematoma combined with Naoxueshu treatment for spontaneous cerebral hemorrhage. Methods:Computer search was conducted on Chinese and English databases including CNKI, VIP, Wanfang, CBM, PubMed, Embase and the Cochrane Library from the establishment of the database to June 2023, based on inclusion and exclusion criteria to select randomized controlled trials (RCTS) of minimally invasive removal of intracranial hematoma combined with Naoxueshu oral liquid in the treatment of spontaneous intracerebral hemorrhage. The risk of bias was evaluated according to the Cochrane Systematic Review Manual, and meta-analysis was performed using Revman5.4 software, and the GRADE system was used to evaluate the evidence quality of outcome indicators. Results:Totally 9 RCTs were included, and the total sample size was 739 cases. There were 371 cases in the control group and 368 cases in the experimental group. The results of meta-analysis showed that compared with only conventional Western medicine after minimally invasive surgery, combined application of Naoxueshu oral liquid improved the overall clinical effectiveness rate [OR=5.47, 95%CI=2.28, 13.09, P=0.000 1], obviously reduced the score of National Institute of Health Stroke Scale [MD=-3.42, 95%CI=-4.97, -1.87, P<0.000 1], and neurological impairment score Chinese stroke patients [MD=-2.30, 95%CI=-3.01, -1.58, P<0.000 01], improved Glasgow Coma Scale score [MD=1.51, 95%CI=1.13, 1.89, P<0.000 01] and Barthel Index (BI) score [MD=6.88, 95%CI=4.49, 9.27, P<0.000 01], and decreased serum S100 protein [MD=-0.02, 95%CI=-0.03, -0.02, P<0.000 01] and AQP4 levels [MD=-0.02, 95%CI=-0.03, -0.01, P=0.002[. In terms of safety, no serious adverse reactions were reported;gastrointestinal discomfort symptoms including nausea, abdominal distension and diarrhea were reported in 2 studies; no adverse reactions were reported in the remaining studies. Conclusion:Existing evidence shows that minimally invasive removal of intracranial hematoma combined with Naoxueshu oral liquid in the treatment of spontaneous cerebral hemorrhage has obvious effects in reducing the degree of neurological impairment and consciousness disorder, improving patients' daily living ability, ameliorating patients' quality of life and other aspects, and has certain safety. [ABSTRACT FROM AUTHOR]