Overexpression of diglucosyldiacylglycerol synthase leads to daptomycin resistance in Bacillus subtilis.

A recent study found that overexpression of the ugtP gene, which encodes a diglucosyldiacylglycerol synthase, leads to daptomycin resistance in Bacillus subtilis. Daptomycin is an antibiotic that works by forming a complex with certain lipids in the bacterial cell membrane, causing membrane perforation. The overexpression of ugtP resulted in an increase in the amount of diglucosyldiacylglycerol (Glc2DAG) and a decrease in other phospholipids, ultimately leading to daptomycin resistance. This research provides insight into the mechanism of bacterial resistance to daptomycin and highlights the importance of understanding these mechanisms to combat antibiotic resistance. [Extracted from the article]