Longitudinal proteomic analysis of T cell differentiation in vivo reveals dynamic changes of the interactome.

A recent preprint abstract discusses the findings of a study on T cell differentiation in vivo using the lymphocytic choriomeningitis virus (LCMV) mouse model. The study aimed to examine the proteomic profiles of T cell differentiation, which had not been extensively studied before. The researchers found dynamic changes in the T cell proteome during differentiation, with some proteins being significantly abundant in specific cell states that were not previously highlighted by transcriptional profiling. This study provides a comprehensive resource for understanding the proteome of in vivo T cell differentiation and its potential therapeutic implications. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]