Researcher at Kanazawa University Discusses Research in Drug Resistance (In Saccharomyces cerevisiae r0 Cells, UME6 Contributes to the Activation of ABC Transporter Genes and Pleiotropic Drug Resistance via RPD3 and PDR3).

A recent report from Kanazawa University in Japan discusses research on drug resistance in Saccharomyces cerevisiae, a type of yeast. The study focuses on the Rpd3L complex, which includes the histone deacetylase Rpd3 and the DNA binding proteins Ume6 and Ash1, and its role in transcriptional regulation. The researchers found that RPD3 and UME6 are responsible for the activation of ABC transporter genes and pleiotropic drug resistance in r0 cells, which lack mitochondrial DNA. This finding may have implications for understanding drug resistance in both yeast and pathogenic Candida species. [Extracted from the article]