Study Findings from University of Toronto Broaden Understanding of Drug-Induced Liver Injury (The role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury).

A recent study conducted by researchers at the University of Toronto has shed light on the mechanisms underlying nevirapine-induced idiosyncratic drug-induced liver injury (IDILI). Nevirapine is an antiretroviral drug used in the treatment of HIV, but its usage has decreased due to concerns about liver injury. The study found that nevirapine induces the release of corticosterone, a hormone that contributes to delayed-onset liver injury. The research suggests that acute glucocorticoid signaling is harmful in the context of nevirapine-induced liver injury and has implications for screening drug candidates for IDILI risk and preventing nevirapine-induced IDILI. [Extracted from the article]