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Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field.

Authors :
Han-Xiao Chen
Xin-Yu Wang
Biao Yu
Chuan-Lin Feng
Guo-Feng Cheng
Lei Zhang
Jun-Jun Wang
Ying Wang
Ruo-Wen Guo
Xin-Miao Ji
Wen-Jing Xie
Wei-Li Chen
Chao Song
Xin Zhang
Source :
Zoological Research; 2024, Vol. 45 Issue 3, p478-490, 13p
Publication Year :
2024

Abstract

Acetaminophen (APAP), the most frequently used mild analgesic and antipyretic drug worldwide, is implicated in causing 46% of all acute liver failures in the USA and between 40% and 70% in Europe. The predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine (NAC); however, its efficacy is limited in cases of advanced liver injury or when administered at a late stage. In the current study, we discovered that treatment with a moderate intensity static magnetic field (SMF) notably reduced the mortality rate in mice subjected to high-dose APAP from 40% to 0%, proving effective at both the initial liver injury stage and the subsequent recovery stage. During the early phase of liver injury, SMF markedly reduced APAPinduced oxidative stress, free radicals, and liver damage, resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione (GSH). During the later stage of liver recovery, application of vertically downward SMF increased DNA synthesis and hepatocyte proliferation. Moreover, the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery, even 24 h post overdose, when the effectiveness of NAC alone substantially declines. Overall, this study provides a noninvasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP overdose. Of note, this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP, and potentially other toxic overdoses. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20958137
Volume :
45
Issue :
3
Database :
Complementary Index
Journal :
Zoological Research
Publication Type :
Academic Journal
Accession number :
177405410
Full Text :
https://doi.org/10.24272/j.issn.2095-8137.2023.410