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Utility of 68Ga-DOTATATE PET-MRI for Gamma Knife® stereotactic radiosurgery treatment planning for meningioma.
- Source :
- British Journal of Radiology; Jan2024, Vol. 97 Issue 1153, p180-185, 6p
- Publication Year :
- 2024
-
Abstract
- Objectives To investigate the impact of adding <superscript>68</superscript>Ga-DOTATATE PET/MRI to standard MRI for target volume delineation in Gamma Knife<superscript>®</superscript> stereotactic radiosurgery (GKSRS) for meningioma. Methods Seventeen patients with 18 lesions undergoing GKSRS for WHO grade 1 meningioma were enrolled in a prospective study. All patients underwent pre-treatment <superscript>68</superscript>Ga-DOTATATE PET/MRI examination in addition to standard procedures. Five clinicians independently contoured the gross tumour volume (GTV) based on standard MRI (GTV<subscript>MRI</subscript>) and PET/MRI (GTV<subscript>PET/MRI</subscript>) on separate occasions. Interobserver agreement was evaluated using Cohen's Kappa statistic (CKS), Dice similarity coefficient (DC), and Hausdorff distance (HD). Statistical analysis was performed with paired t -test and Wilcoxon signed rank test. Results The addition of PET/MRI significantly increased GTV contour volume (mean GTV<subscript>PET/MRI</subscript> 3.59 cm<superscript>3</superscript> versus mean GTV<subscript>MRI</subscript> 3.18 cm<superscript>3</superscript>, P = .008). Using the treating clinician's pre-treatment GTV<subscript>MRI</subscript> as the reference, median CKS (87.2 vs 77.5, P = .006) and DC (87.2 vs 77.4, P = .006) were significantly lower, and median HD (25.2 vs 31.0, P = .001) was significantly higher with the addition of PET/MRI. No significant difference was observed in interobserver contouring reproducibility between GTV<subscript>MRI</subscript> and GTV<subscript>PET/MRI</subscript>. Conclusion The addition of <superscript>68</superscript>Ga-DOTATATE PET/MRI for target volume delineation in GKSRS for meningioma is associated with an increase in GTV volume and greater interobserver variation. PET/MRI did not affect interobserver contouring reproducibility. Advances in Knowledge This study provides novel insights into the impact of <superscript>68</superscript>Ga-DOTATATE PET/MRI on GTV delineation and interobserver agreement in meningioma GKSRS, highlighting its potential for improving GKSRS treatment accuracy. [ABSTRACT FROM AUTHOR]
- Subjects :
- STEREOTACTIC radiosurgery
COHEN'S kappa coefficient (Statistics)
MENINGIOMA
Subjects
Details
- Language :
- English
- ISSN :
- 00071285
- Volume :
- 97
- Issue :
- 1153
- Database :
- Complementary Index
- Journal :
- British Journal of Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 177378422
- Full Text :
- https://doi.org/10.1093/bjr/tqad026