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The importance of the enzyme Gamma-glutamyltransferase in the pathogenic cluster in type2 diabetic patient.
- Source :
- Romanian Journal of Internal Medicine; Jun2024, Vol. 62 Issue 2, p203-209, 7p
- Publication Year :
- 2024
-
Abstract
- Introduction. Gamma-glutamyltransferase (GGT) is a liver enzyme involved in inflammation and oxidative stress. It is already known that MCP-1 (Monocyte Chemoattractant Protein-1) and TNF-α (tumour necrosis factor) as inflammatory markers, ICAM-1 (Intercellular Adhesion Molecule-1) as an endothelial dysfunctional marker, and glutathione, as an antioxidant, have abnormal levels in type 2 diabetic patients. The aim of this study was to evaluate the specific biological picture of type 2 diabetic patients that also associate higher GGT activity. Methods. Eighty-five type 2 diabetes, aged 40–70 years with a duration of diabetes less than 6 years without infections, epilepsy, chronic liver or cardiac diseases, without alcohol consumption (>20 g/day) were divided in two subgroups, those with normal and those with high abnormal GGT. Results. The diabetic patients with high GGT (n=31) had dysglycaemia, dyslipidemia, higher inflammatory markers (CRP, TNF-α, MCP-1) and endothelial dysfunction (high leptin and sICAM). sICAM, serum MCP-1 and TNF-α levels had significant correlations with GGT activity (r= 0.38, r=0.30 and 0.26 respectively, p<0.05). Conclusion. This study underlines that in non-alcoholic diabetic patients, with a duration of the metabolic disease less than 6 years, sICAM, serum MCP-1 and TNF-α might play an important role in dysmetabolism, and higher level for GGT represents the „red flag" for this condition. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15823296
- Volume :
- 62
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Romanian Journal of Internal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 177376515
- Full Text :
- https://doi.org/10.2478/rjim-2024-0006