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Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor.
- Source :
- National Science Review; Apr2024, Vol. 11 Issue 4, p1-10, 10p
- Publication Year :
- 2024
-
Abstract
- The limited infiltration and persistence of chimeric antigen receptor (CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading, delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20955138
- Volume :
- 11
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- National Science Review
- Publication Type :
- Academic Journal
- Accession number :
- 177357810
- Full Text :
- https://doi.org/10.1093/nsr/nwae018