Back to Search
Start Over
Prime editing and its application in beta-hemoglobinopathies.
- Source :
- Nucleus (0029568X); Apr2024, Vol. 67 Issue 1, p227-235, 9p
- Publication Year :
- 2024
-
Abstract
- Genome-editing technologies have provided researchers with the ability to edit DNA mutations associated with various genetic diseases. Prime editing, a 'search-and-replace' gene-editing technology, can correct any base-to-base substitutions, small insertions, and small deletions without requiring double-stranded breaks. Beta-hemoglobinopathies, such as beta-thalassemia and sickle cell anemia, are common monogenic disorders caused by mutations in the beta-globin gene, which alter adult hemoglobin production. Prime editing, the latest genome editing technology, has shown the potential to cure beta-thalassemia and sickle cell anemia by correcting pathogenic mutations. This review presents a basic principle, innovations, delivery strategies, advantages, limitations, and improvements of prime editing, as well as the potential of prime editing to cure beta-thalassemia and sickle cell anemia. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0029568X
- Volume :
- 67
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Nucleus (0029568X)
- Publication Type :
- Academic Journal
- Accession number :
- 177350459
- Full Text :
- https://doi.org/10.1007/s13237-024-00470-w