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Rhodium‐Catalyzed Enantio‐ and Regioselective Allylation of Indoles with gem‐Difluorinated Cyclopropanes.
- Source :
- Angewandte Chemie International Edition; 5/27/2024, Vol. 63 Issue 22, p1-7, 7p
- Publication Year :
- 2024
-
Abstract
- The use of gem‐difluorinated cyclopropanes (gem‐DFCPs) as fluoroallyl surrogates under transition‐metal catalysis has drawn considerable attention recently but such reactions are restricted to producing achiral or racemic mono‐fluoroalkenes. Herein, we report the first enantioselective allylation of indoles under rhodium catalysis with gem‐DFCPs. This reaction shows exceptional branched regioselectivity towards rhodium catalysis with gem‐DFCPs, which provides an efficient route to enantioenriched fluoroallylated indoles with wide substrate scope and good functional group tolerance. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALLYLATION
INDOLE compounds
RHODIUM
FUNCTIONAL groups
CATALYSIS
INDOLE
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 63
- Issue :
- 22
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 177321172
- Full Text :
- https://doi.org/10.1002/anie.202403602