New Legionnaires' Disease Findings from University of California San Francisco (UCSF) Reported (Cross-family Small Gtpase Ubiquitination By the Intracellular Pathogen Legionella Pneumophila).

A recent study conducted by researchers at the University of California San Francisco (UCSF) has shed light on the mechanisms by which the intracellular pathogen Legionella pneumophila (L.p.) manipulates host cells during infection. The study found that L.p. increases the ubiquitination of host regulators involved in subcellular trafficking and membrane dynamics, particularly small GTPases. The bacterial effectors SidC/SdcA were identified as playing a central role in the ubiquitination of small GTPases, which is a novel consequence of L.p. infection. These findings provide valuable insights into the regulation of small GTPases by ubiquitination in uninfected contexts. [Extracted from the article]