Back to Search
Start Over
Quetiapine attenuates cadmium neurotoxicity by suppressing oxidative stress, inflammation, and pyroptosis.
- Source :
- Molecular Biology Reports; 5/15/2024, Vol. 51 Issue 1, p1-16, 16p
- Publication Year :
- 2024
-
Abstract
- Background: Cadmium (Cd) is a heavy metal with extremely harmful toxic effects on the brain. Quetiapine (QTP) has unique neuroprotective effects with anti-inflammatory and antioxidant actions. However, its neuroprotective effect against Cd-induced neurotoxicity has not been previously studied. Methods: QTP was administered in 10 and 20 mg/kg doses, while Cd was given in a dose of 6.5 mg/kg. Results: In our study, QTP dose-dependently attenuated neuronal injury by downregulating p-tau and β-amyloid. QTP potently attenuates histological abrasions induced by Cd. QTP counteracted oxidative injury by decreasing neuronal MDA and increased GSH levels mediated by downregulating Keap1 and upregulating Nrf2 and HO-1. QTP mitigated inflammation by decreasing MPO and NO<subscript>2</subscript> and neuronal cytokines TNF-α and IL-1β and upregulating IL-10 levels mediated by NF-κB downregulation. Additionally, QTP counteracted Cd-induced pyroptosis by downregulating caspase-1, ASC, and NLRP3 protein levels. Conclusion: In conclusion, QTP mitigates neurotoxicity induced by Cd through suppression of inflammation, pyroptosis, and oxidative stress by controlling the NF-κB, Keap1/Nrf2, and pyroptosis signals. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03014851
- Volume :
- 51
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Molecular Biology Reports
- Publication Type :
- Academic Journal
- Accession number :
- 177250255
- Full Text :
- https://doi.org/10.1007/s11033-024-09558-7