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Epitope Mapping of SARS-CoV-2 Spike Antibodies in Vaccinated Kidney Transplant Recipients Reveals Poor Spike Coverage Compared to Healthy Controls.

Authors :
Karaba, Andrew H
Morgenlander, William R
Johnston, Trevor S
Hage, Camille
Pekosz, Andrew
Durand, Christine M
Segev, Dorry L
Robien, Mark A
Heeger, Peter S
Larsen, Christian P
Blankson, Joel N
Werbel, William A
Larman, H Benjamin
Tobian, Aaron A R
Source :
Journal of Infectious Diseases; 5/15/2024, Vol. 229 Issue 5, p1366-1371, 6p
Publication Year :
2024

Abstract

Kidney transplant recipients (KTRs) develop decreased antibody titers to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination compared to healthy controls (HCs), but whether KTRs generate antibodies against key epitopes associated with neutralization is unknown. Plasma from 78 KTRs from a clinical trial of third doses of SARS-CoV-2 vaccines and 12 HCs underwent phage display immunoprecipitation and sequencing (PhIP-Seq) to map antibody responses against SARS-CoV-2. KTRs had lower antibody reactivity to SARS-CoV-2 than HCs, but KTRs and HCs recognized similar epitopes associated with neutralization. Thus, epitope gaps in antibody breadth of KTRs are unlikely responsible for decreased efficacy of SARS-CoV-2 vaccines in this immunosuppressed population. Clinical Trials Registration.  NCT04969263. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00221899
Volume :
229
Issue :
5
Database :
Complementary Index
Journal :
Journal of Infectious Diseases
Publication Type :
Academic Journal
Accession number :
177249749
Full Text :
https://doi.org/10.1093/infdis/jiad534