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Risk factors for hemorrhagic cystitis in children undergoing hematopoietic stem cell transplantation: a systematic review and meta-analysis.
- Source :
- BMC Pediatrics; 5/14/2024, Vol. 24 Issue 1, p1-11, 11p
- Publication Year :
- 2024
-
Abstract
- Background: The risk factors for hemorrhagic cystitis (HC) in children undergoing hematopoietic stem cell transplantation (HSCT) are unclear. Therefore, we conducted this systematic review and meta-analysis to investigate the risk factors for HC in children undergoing HSCT. Methods: We performed this meta-analysis by retrieving studies from PubMed, EMBASE, and the Cochrane Library up to October 10, 2023, and analyzing those that met the inclusion criteria. I<superscript>2</superscript> statistics were used to evaluate heterogeneity. Results: Twelve studies, including 2,764 patients, were analyzed. Male sex (odds ratio [OR] = 1.52; 95% confidence interval [CI], 1.16–2.00; p = 0.003, I<superscript>2</superscript> = 0%), allogeneic donor (OR = 5.28; 95% CI, 2.60–10.74; p < 0.00001, I<superscript>2</superscript> = 0%), human leukocyte antigen (HLA) mismatched donor (OR = 1.86; 95% CI, 1.00–3.44; p = 0.05, I<superscript>2</superscript> = 31%), unrelated donor (OR = 1.58; 95% CI, 1.10–2.28; p = 0.01, I<superscript>2</superscript> = 1%), myeloablative conditioning (MAC) (OR = 3.17; 95% CI, 1.26–7.97; p = 0.01, I<superscript>2</superscript> = 0%), busulfan (OR = 2.18; 95% CI, 1.33–3.58; p = 0.002, I<superscript>2</superscript> = 0%) or anti-thymoglobulin (OR = 1.65; 95% CI, 1.07–2.54; p = 0.02, I<superscript>2</superscript> = 16%) use, and cytomegalovirus (CMV) reactivation (OR = 2.64; 95% CI, 1.44–4.82; p = 0.002, I<superscript>2</superscript> = 0%) were risk factors for HC in children undergoing HSCT. Conclusions: Male sex, allogeneic donor, HLA-mismatched, unrelated donor, MAC, use of busulfan or anti-thymoglobulin, and CMV reactivation are risk factors for HC in children undergoing HSCT. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14712431
- Volume :
- 24
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 177220269
- Full Text :
- https://doi.org/10.1186/s12887-024-04815-x