S‐adenosyl methionine‐AMP opens another skylight of CRISPR system: discovering novel second messenger for bacterial antiviral immunity.

A recent article in the journal MedComm discusses the discovery of S-adenosyl methionine (SAM)-AMP as a novel class of second messengers for antiviral signals in bacterial defense systems. The study focuses on the type III CRISPR-Cas system and its unique characteristics in RNA cleavage and RNA-activated DNA cleavage for antiviral defense. The researchers identified SAM-AMP as a signaling molecule and found that it plays a role in bacterial antiviral immune defense. This discovery expands our understanding of bacterial molecules and sheds light on the evolutionary relationship between prokaryotic and eukaryotic signaling pathways. [Extracted from the article]