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The effects of myosteatosis on skeletal muscle function in older adults.
- Source :
- Physiological Reports; May2024, Vol. 12 Issue 9, p1-11, 11p
- Publication Year :
- 2024
-
Abstract
- Myosteatosis, or the infiltration of fatty deposits into skeletal muscle, occurs with advancing age and contributes to the health and functional decline of older adults. Myosteatosis and its inflammatory milieu play a larger role in adipose tissue dysfunction, muscle tissue dysfunction, and increased passive muscle stiffness. Combined with the age‐related decline of sex hormones and development of anabolic resistance, myosteatosis also contributes to insulin resistance, impaired muscle mechanics, loss of force production from the muscle, and increased risk of chronic disease. Due to its highly inflammatory secretome and the downstream negative effects on muscle metabolism and mechanics, myosteatosis has become an area of interest for aging researchers and clinicians. Thus far, myosteatosis treatments have had limited success, as many lack the potency to completely rescue the metabolic and physical consequences of myosteatosis. Future research is encouraged for the development of reliable assessment methods for myosteatosis, as well as the continued exploration of pharmacological, nutritional, and exercise‐related interventions that may lead to the success in attenuating myosteatosis and its clinical consequences within the aging population. [ABSTRACT FROM AUTHOR]
- Subjects :
- OLDER people
SKELETAL muscle
MUSCLE metabolism
INSULIN resistance
ADIPOSE tissues
Subjects
Details
- Language :
- English
- ISSN :
- 2051817X
- Volume :
- 12
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Physiological Reports
- Publication Type :
- Academic Journal
- Accession number :
- 177219679
- Full Text :
- https://doi.org/10.14814/phy2.16042