Application of ultrasonography and 99mTc-MIBI scintigraphy in the diagnosis and localization of hyperparathyroidism.

Background: The To discuss the application value of ultrasonography (US) and ^99mTc-methoxyisobutylisonitrile (^99mTc-MIBI) scintigraphy in hyperparathyroidism (HPT), so as to provide a more reliable guarantee for surgery or thermal ablation. Materials and Methods: Sixty-four HPT patients admitted to our hospital and the Tenth People's Hospital of Tongji University from January 2018 to February 2023 were selected as research participants. All patients underwent cervical US, dual-phase ^99mTc-MIBI planar scintigraphy, single photon emission computed tomography (SPECT), and pathological examination. The diagnostic efficiency of the above three imaging modalities was evaluated with pathological findings as the gold standard. In addition, the influence of parathyroid position, size and histological type on imaging results was evaluated. Results: Among the 64 patients, 71 positive lesions were pathologically confirmed. The analysis showed that ^99mTc-MIBI SPECT/CT (Kappa=0.806) and US (Kappa=0.686) had high consistency with pathological findings, while dual-phase ^99mTc-MIBI planar scintigraphy had moderate consistency with pathological examination results (Kappa=0.594). Conclusions: 99mTc-MIBI scintigraphy can significantly improve the diagnostic rate of parathyroid lesions. US is first recommended for patients suspected of HPT, followed by ^99mTc-MIBI scintigraphy for confirmation. [ABSTRACT FROM AUTHOR]