Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response.

A preprint abstract from biorxiv.org discusses the function of the protein kinase CDK2 in fish. The study found that CDK2 negatively regulates the expression of interferon (IFN), an antiviral cytokine, in fish. CDK2 was found to bind and degrade TBK1, resulting in reduced IFN expression. The study suggests that CDK2 in lower vertebrates plays a specialized role in antiviral innate immunity. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]