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A Novel Insulin Delivery Algorithm in Rats With Type 1 Diabetes: The Fading Memory Proportional-Derivative Method.
- Source :
- Artificial Organs; Aug2005, Vol. 29 Issue 8, p599-607, 9p
- Publication Year :
- 2005
-
Abstract
- An algorithm designed to automatically control insulin delivery was tested in rats with Type 1 diabetes. This nonlinear algorithm included a fading memory component of proportional and derivative errors in order to simulate normal insulin secretion. Error-weighting functions for the proportional and derivative terms were used with a performance index designed for error adaptation. In the first version of the algorithm, the proportional gain was adaptively varied. In the second version, a low rate of basal insulin delivery was adaptively varied. Six 6-h studies with each version were conducted using frequent blood sampling and intravenous insulin delivery. In Version 2 studies, blood glucose levels during the last two hours were well-controlled and significantly lower than in Version 1 (118 ± 2.0 vs. 130 ± 2.9 mg/dL). Neither version produced hypoglycemia. Future research using this algorithm needs to focus on automated glucose sensing in combination with insulin delivery. [ABSTRACT FROM AUTHOR]
- Subjects :
- INSULIN
DRUG delivery systems
ALGORITHMS
DIABETES
INTRAVENOUS therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0160564X
- Volume :
- 29
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Artificial Organs
- Publication Type :
- Academic Journal
- Accession number :
- 17715226
- Full Text :
- https://doi.org/10.1111/j.1525-1594.2005.29096.x