Studies from Graduate School of Medicine Add New Findings in the Area of Peptide Receptors (Lcz696, an Angiotensin Receptor-neprilysin Inhibitor, Ameliorates Endothelial Dysfunction In Diabetic C57bl/6 Mice).

A recent study conducted by researchers at the Graduate School of Medicine in Osaka, Japan, explored the effects of LCZ696, an angiotensin receptor-neprilysin inhibitor, on endothelial dysfunction in diabetic mice. The study found that LCZ696 improved endothelium-dependent vascular relaxation in diabetic mice, potentially through increased bioavailability of atrial natriuretic peptide (ANP). The researchers concluded that LCZ696 may have a vascular protective effect in diabetic models and could be more effective than valsartan. This research has been peer-reviewed and published in the Journal of Atherosclerosis and Thrombosis. [Extracted from the article]