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Unlocking the potential: phenylboronic acid as a nuclear-targeting boron agent for neutron capture therapy.

Authors :
Chen, Jiejian
Li, Yonghao
Gan, Xiaoning
Weng, Chengyin
Fang, Xisheng
Liu, Guolong
Source :
Medical Oncology; May2024, Vol. 41 Issue 5, p1-5, 5p
Publication Year :
2024

Abstract

It has been proposed that boron neutron capture therapy (BNCT) holds promise as a treatment modality for melanoma. However, the effectiveness of boron agents in delivery remains a critical issue to be addressed for BNCT. To this end, phenylboronic acid, which exhibits good water solubility and low cytotoxicity similar to BPA, has been investigated as a potential nuclear-targeting boron agent. The boron concentration of phenylboronic acid was found to be 74.47 ± 12.17 ng/10<superscript>6</superscript> B16F10 cells and 45.77 ± 5.64 ng/10<superscript>6</superscript> cells in the nuclei. Molecular docking experiments were conducted to investigate the binding of phenylboronic acid to importin proteins involved in nuclear transport. The potential of phenylboronic acid to serve as a desirable nucleus-delivery boron agent for neutron capture therapy in melanoma warrants further exploration. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13570560
Volume :
41
Issue :
5
Database :
Complementary Index
Journal :
Medical Oncology
Publication Type :
Academic Journal
Accession number :
177148248
Full Text :
https://doi.org/10.1007/s12032-024-02351-3