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Cumulative environmental stress and emerging cardiometabolic risk during childhood.
- Source :
- Pediatric Obesity; Jun2024, Vol. 19 Issue 6, p1-9, 9p
- Publication Year :
- 2024
-
Abstract
- Summary: Objective: To prospectively evaluate the relationship between cumulative environmental stress and cardiometabolic risk in middle childhood, and to examine whether hair cortisol, a measure of hypothalamic pituitary adrenal‐axis activity, mediates this relationship. Methods: In a cohort of children from low‐income households (n = 320; 59% Hispanic, 23% Black, body mass index (BMI) percentile >50th at enrollment), environmental stressors including family and neighbourhood factors representing disadvantage/deprivation, and cortisol concentrations from hair samples, were measured over five timepoints beginning when children were 2–4 years old. Cardiometabolic risk factors (i.e., BMI, blood pressure, lipids, blood sugar, C‐reactive protein) were measured at the final timepoint when children were 7–11 years of age. Results: In adjusted logistic regression models, greater cumulative environmental stress was associated with a higher likelihood of elevated cardiometabolic risk in middle childhood (p = 0.01). Children from minoritized racial/ethnic groups had a higher prevalence of both stressors and cardiometabolic risk factors. Cumulative environmental stress was associated with higher hair cortisol concentrations (p < 0.01). However, hair cortisol was not directly associated with cardiometabolic risk factors and did not explain the association between environmental stress and cardiometabolic risk in causal mediation analysis. Conclusions: The influence of cumulative stress on cardiometabolic health can be observed in middle childhood and may contribute to cardiometabolic health disparities, highlighting the importance of public health interventions to mitigate disadvantage. [ABSTRACT FROM AUTHOR]
- Subjects :
- BLOOD sugar analysis
RISK assessment
STATISTICAL correlation
HAIR analysis
AFRICAN Americans
BODY mass index
RESEARCH funding
HISPANIC Americans
LIPIDS
LOGISTIC regression analysis
FAMILIES
CARDIOVASCULAR diseases risk factors
HYDROCORTISONE
DESCRIPTIVE statistics
AGE distribution
DISEASE prevalence
LONGITUDINAL method
RACE
PSYCHOLOGICAL stress
HYPOTHALAMIC-pituitary-adrenal axis
RESEARCH
FACTOR analysis
MINORITIES
HEALTH equity
NEIGHBORHOOD characteristics
POVERTY
BLOOD pressure measurement
SOCIAL isolation
C-reactive protein
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 20476302
- Volume :
- 19
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Pediatric Obesity
- Publication Type :
- Academic Journal
- Accession number :
- 177146240
- Full Text :
- https://doi.org/10.1111/ijpo.13116