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A Mendelian randomized study on the causal relationship between blood metabolites and heart failure.
- Source :
- Modern Preventive Medicine; Apr2024, Vol. 51 Issue 7, p1320-1324, 5p
- Publication Year :
- 2024
-
Abstract
- Objective To evaluate the potential causal relationship between blood metabolites and the risk of heart failure by two-sample Mendelian randomization. Methods Based on a genome-wide association study containing 486 blood metabolites, single nucleotide polymorphisms (SNPs) independently associated with blood metabolites was selected as instrumental variables. The heart failure data were derived from the Genome-Wide Association Study of the Molecular Epidemiology Research Consortium for Therapeutic Targets in Heart Failure. The potential causal relationship between them was analyzed by inverse variance weighting method, MR-Egger regression method, and weighted median method, and the sensitivity analysis was performed using MR-Egger regression intercept, Cochran Q test, MR-PRESSO, and leave-one-out method. Results In total 7 516 SNP associated with blood metabolites were selected as instrumental variables. The results of inverse variance weighting analysis showed that pantothenic acid was associated with heart failure (OR=1.29, 95% CI: 1.03-1.63). Sensitivity analysis results indicated that the results were robust. Conclusion This study suggests that there is a positive causal relationship between pantothenic acid and the risk of heart failure, which may provide new insights into the pathogenesis and drug targets of heart failure. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Chinese
- ISSN :
- 10038507
- Volume :
- 51
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Modern Preventive Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 177138847
- Full Text :
- https://doi.org/10.20043/j.cnki.MPM.202311513