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Psychophysical, electrofunctional, and morphological evaluation in naïve neovascular AMD patients treated with intravitreal anti‐VEGF.
- Source :
- Aging Medicine; Apr2024, Vol. 7 Issue 2, p189-201, 13p
- Publication Year :
- 2024
-
Abstract
- Objectives: The aim of this study was to investigate the retinal morpho‐functional characteristics of patients with neovascular wet age‐related macular degeneration (nAMD) treated with intravitreal injection (IV) of aflibercept (AFL). Methods: The study was conducted on 35 patients previously diagnosed with type 1 nAMD who received a fixed‐dosing regimen of aflibercept injections over 12 months. The goal was to assess trends in visual abilities over time by measuring visual acuity (VA), contrast sensitivity (CS), visual evoked potentials (VEPs), and spectral domain‐optical coherence tomography (SD‐OCT). The same psychophysical, electro‐functional, and morphological tests administered at baseline (T0) were repeated 4 to 8 weeks after the last aflibercept injection (Tn), resulting in a total of six examinations. Results: At Tn, all subjects exhibited improved VA for both far and near distances compared to values detected at T0. Similarly, VEP amplitude and latency values at Tn showed a greater P100 improvement than those observed at T0. Additionally, the CS examination at Tn demonstrated improvement, particularly at high spatial stimulation frequencies. The Tn SD‐OCT results highlighted a reduction in macular thickness compared to T0 values. Conclusions: This exploratory research indicates that intravitreal injections of AFL, following a fixed‐dosing regimen, represent a valuable therapeutic approach for enhancing visual performance. This conclusion is supported by comprehensive statistical analysis of psychophysical, electro‐functional, and morphological examinations within the same group of patients with nAMD, as demonstrated for the first time. [ABSTRACT FROM AUTHOR]
- Subjects :
- RETINA physiology
RETINAL anatomy
VASCULAR endothelial growth factor antagonists
PSYCHOPHYSIOLOGY
DATA analysis
RETINAL degeneration
INTRAVITREAL injections
OPTICAL coherence tomography
VISUAL evoked response
SCIENTIFIC observation
VISION testing
NEOVASCULARIZATION inhibitors
TREATMENT effectiveness
DESCRIPTIVE statistics
LONGITUDINAL method
RECOMBINANT proteins
RESEARCH
FRIEDMAN test (Statistics)
STATISTICS
PATHOLOGIC neovascularization
VISUAL acuity
CONFIDENCE intervals
ELECTROPHYSIOLOGY
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 24750360
- Volume :
- 7
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Aging Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 177113812
- Full Text :
- https://doi.org/10.1002/agm2.12296