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Homoharringtonine: updated insights into its efficacy in hematological malignancies, diverse cancers and other biomedical applications.

Authors :
Khatua, Somanjana
Nandi, Sudeshna
Nag, Anish
Sen, Surjit
Chakraborty, Nilanjan
Naskar, Arghya
Gürer, Eda Sönmez
Calina, Daniela
Acharya, Krishnendu
Sharifi-Rad, Javad
Source :
European Journal of Medical Research; 5/4/2024, Vol. 29 Issue 1, p1-25, 25p
Publication Year :
2024

Abstract

HHT has emerged as a notable compound in the realm of cancer treatment, particularly for hematological malignancies. Its multifaceted pharmacological properties extend beyond traditional applications, warranting an extensive review of its mechanisms and efficacy. This review aims to synthesize comprehensive insights into the efficacy of HHT in treating hematological malignancies, diverse cancers, and other biomedical applications. It focuses on elucidating the molecular mechanisms, therapeutic potential, and broader applications of HHT. A comprehensive search for peer-reviewed papers was conducted across various academic databases, including ScienceDirect, Web of Science, Scopus, American Chemical Society, Google Scholar, PubMed/MedLine, and Wiley. The review highlights HHT's diverse mechanisms of action, ranging from its role in leukemia treatment to its emerging applications in managing other cancers and various biomedical conditions. It underscores HHT's influence on cellular processes, its efficacy in clinical settings, and its potential to alter pathological pathways. HHT demonstrates significant promise in treating various hematological malignancies and cancers, offering a multifaceted approach to disease management. Its ability to impact various physiological pathways opens new avenues for therapeutic applications. This review provides a consolidated foundation for future research and clinical applications of HHT in diverse medical fields. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09492321
Volume :
29
Issue :
1
Database :
Complementary Index
Journal :
European Journal of Medical Research
Publication Type :
Academic Journal
Accession number :
177044335
Full Text :
https://doi.org/10.1186/s40001-024-01856-x