Studies from Anhui Normal University Reveal New Findings on Alzheimer Disease (A Facile Two-photon Red-emission Fluorescent Marker With a Large Stokes Shift For In Vivo Brain Imaging of Amyloid-beta Aggregates).

Researchers from Anhui Normal University in Wuhu, China have developed a fluorescent probe called BTD-A13 that can be used for brain imaging of amyloid-beta (A13) aggregates in Alzheimer's disease (AD). The probe has a low molecular weight, large two-photon absorption cross-section, red emission, and a large Stokes shift. It also demonstrates improved sensing and imaging capabilities, including faster response, higher binding affinity, selectivity, and good blood-brain barrier penetration. The probe has been successfully used for in situ observation of A13 aggregates in brain-derived endothelial cells and in vivo brain imaging in AD mice. [Extracted from the article]