Findings from Huazhong University of Science and Technology Provides New Data about Biomarkers (Thymic Stromal Lymphopoietin Suppresses Markers of Neuroinflammation and the Jak2/stat5 Pathway In Activated Microglia).

A study conducted by researchers at Huazhong University of Science and Technology in Wuhan, China, has found that thymic stromal lymphopoietin (TSLP) may play a role in reducing neuroinflammation in the central nervous system. The researchers used a model of LPS-stimulated microglia to investigate the impact of TSLP on microglial activation and found that TSLP treatment increased the expression of TSLP receptors and reduced oxidative stress, inflammation, and the expression of M1-type markers in microglia. TSLP also influenced the differentiation of microglia towards the M2 type and suppressed LPS-induced activation through the JAK2/STAT5 pathway. The study suggests that targeting TSLP could be a novel strategy for controlling inflammation in the central nervous system. [Extracted from the article]