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Novel Oral Polio Vaccine Type 2 Use for Polio Outbreak Response: A Global Effort for a Global Health Emergency.

Authors :
Kurji, Feyrouz Damji
Bandyopadhyay, Ananda Sankar
Zipursky, Simona
Cooper, Laura V.
Gast, Chris
Toher, Margaret
Clemens, Ralf
Clemens, Sue Ann Costa
Prasad, Rayasam
Azhari, Adriansjah
Source :
Pathogens; Apr2024, Vol. 13 Issue 4, p273, 14p
Publication Year :
2024

Abstract

A sharp rise in circulating vaccine-derived poliovirus type 2 (cVDPV2) outbreaks in the years following the cessation of routine use of poliovirus type 2-containing oral polio vaccine and the trend of seeding new emergences with suboptimal vaccination response during the same time-period led to the accelerated development of the novel oral polio vaccine type 2 (nOPV2), a vaccine with enhanced genetic stability and lower likelihood of reversion to neuroparalytic variants compared to its Sabin counterpart. In November 2020, nOPV2 became the first vaccine to be granted an Emergency Use Listing (EUL) by the World Health Organization (WHO) Prequalification Team (PQT), allowing close to a billion doses to be used by countries within three years after its first rollout and leading to full licensure and WHO prequalification (PQ) in December 2023. The nOPV2 development process exemplifies how scientific advances and innovative tools can be applied to combat global health emergencies in an urgent and adaptive way, building on a collaborative effort among scientific, regulatory and implementation partners and policymakers across the globe. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20760817
Volume :
13
Issue :
4
Database :
Complementary Index
Journal :
Pathogens
Publication Type :
Academic Journal
Accession number :
176907873
Full Text :
https://doi.org/10.3390/pathogens13040273