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Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY.
- Source :
- Journal of Functional Biomaterials; Apr2024, Vol. 15 Issue 4, p92, 11p
- Publication Year :
- 2024
-
Abstract
- Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Light-controllable NO releasers show promise in the development of smart therapies. Here, we present a novel biocompatible material based on polydimethylsiloxane (PDMS) doped with BODIPY derivatives containing an N-nitroso moiety that is capable of the photoinduced generation of NO. We study the green-light-induced NO-release properties with the following three methods: electrochemical gas-phase sensor, liquid-phase sensor, and the Griess assay. Prolonged release of NO from the polymer films after short irradiation by narrow-band LED light sources and a laser beam is demonstrated. Importantly, this was accompanied by no or little release of the parent compound (BODIPY-based photodonor). Silicone films with the capability of controllable and clean NO release can potentially be used as a highly portable NO delivery system for different therapeutic applications. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20794983
- Volume :
- 15
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Functional Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 176880468
- Full Text :
- https://doi.org/10.3390/jfb15040092