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Impact of Interfering Substances on the Bactericidal Efficacy of Different Commercially Available Hypochlorous Acid-Based Wound Irrigation Solutions Commonly Found in South-East Asia.
- Source :
- Antibiotics (2079-6382); Apr2024, Vol. 13 Issue 4, p309, 9p
- Publication Year :
- 2024
-
Abstract
- The high prevalence of chronic wounds is a growing concern. Recently, hypochlorous acid (HOCl)-based solutions were introduced as an alternative antimicrobial for wound cleansing. In this study, we assessed the in vitro bactericidal activities of seven commercially available wound irrigation products commonly found in South-East Asia. The evaluation was conducted using quantitative suspension method, EN 13727 in either low or high protein conditions. Under low protein conditions, four out of the five HOCl products achieved bactericidal activity (≥5 log<subscript>10</subscript> reduction factor; RF) within 2–5 min, and only one product achieved 5 log<subscript>10</subscript> RF at 15 s. None of the HOCl achieved 5 log<subscript>10</subscript> RF under high protein, even after 30 min of exposure time. In contrast, protein interference on the antimicrobial activities of polyhexamethylene biguanide-based product is less pronounced (low protein: 60 s vs. high protein: 2 min to attain ≥5 log<subscript>10</subscript> RF). Octenidine dihydrochloride is the only active not affected by protein interference achieving ≥5 log<subscript>10</subscript> RF within 15 s in both low and high protein conditions. These findings warrant the need to screen antimicrobial wound care products, especially HOCl-based products, in high protein condition to better reflect the antimicrobial activities in wound care. [ABSTRACT FROM AUTHOR]
- Subjects :
- WOUND care
CHRONIC wounds & injuries
HYPOCHLORITES
ANTI-infective agents
Subjects
Details
- Language :
- English
- ISSN :
- 20796382
- Volume :
- 13
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Antibiotics (2079-6382)
- Publication Type :
- Academic Journal
- Accession number :
- 176875222
- Full Text :
- https://doi.org/10.3390/antibiotics13040309