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Bisphenol A Exposure Interferes with Reproductive Hormones and Decreases Sperm Counts: A Systematic Review and Meta-Analysis of Epidemiological Studies.
- Source :
- Toxics; Apr2024, Vol. 12 Issue 4, p294, 17p
- Publication Year :
- 2024
-
Abstract
- Bisphenol A (BPA), an acknowledged endocrine disrupter, is easily exposed to humans via food packaging and container. However, a consensus has not been reached on the extent to which BPA exposure affects the reproductive system. We therefore conducted this systematic review and meta-analysis to elucidate the relationship between BPA exposure and male reproduction-related indicators. Up to October 2023, a comprehensive search was carried out in the PubMed, Embase, Cochrane and Web of Science, and 18 studies were ultimately included. β coefficients from multivariate linear regression analyses were pooled using a random effects model. The results showed that the urinary BPA concentration was negatively correlated with the sperm concentration (β coefficient = −0.03; 95% CI: −0.06 to −0.01; I<superscript>2</superscript> = 0.0%, p = 0.003) and total sperm count (β coefficient = −0.05; 95% CI: −0.08 to −0.02; I<superscript>2</superscript> = 0.0%, p < 0.001). In addition, BPA concentrations were associated with increased sex hormone-binding globulin (SHBG) levels, increased estradiol (E<subscript>2</subscript>) levels, and reduced biologically active androgen levels. However, the relationship between an increased risk of below-reference sperm quality and BPA exposure was not robust. This systematic review revealed that BPA exposure disrupts reproductive hormones, reduces sperm counts and may ultimately adversely affect male reproduction. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 23056304
- Volume :
- 12
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Toxics
- Publication Type :
- Academic Journal
- Accession number :
- 176874912
- Full Text :
- https://doi.org/10.3390/toxics12040294