The impact of high nicotine concentrations on the viability and cardiac differentiation of mesenchymal stromal cells: a barrier to regenerative therapy for smokers.

This article discusses the effects of nicotine on mesenchymal stromal cells (MSCs) and their potential use in regenerative therapy for cardiovascular disease. The study found that nicotine reduces the viability and proliferation of MSCs, as well as inhibiting their differentiation into cardiac-specific cells. This suggests that nicotine may hinder the regenerative properties of MSCs, which could be problematic for smokers with cardiovascular disease. The article also highlights the role of nicotine acetylcholine receptors in mediating these effects and calls for further research to optimize stem cell therapy for patients. [Extracted from the article]