Research Reports on Neuroblastomas from University of Cagliari Provide New Insights (Oleoylethanolamide and Palmitoylethanolamide Enhance IFNb-Induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells).

A research report from the University of Cagliari in Italy discusses the role of two endogenous lipids, oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), in neuroblastomas. The study investigates the effects of OEA and PEA on human neuroblastoma cells treated with type I interferons (IFNs), which are used in the treatment of various cancers. The researchers found that co-exposure to OEA or PEA with IFNb led to increased apoptotic cell death and decreased cell survival and proliferation. The study also revealed a novel mechanism by which OEA and PEA can impair cell survival through modulating the intrinsic apoptotic pathway. [Extracted from the article]