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Network Pharmacology, Molecular Docking, and Experimental Verification to Reveal the Mitophagy-Associated Mechanism of Tangshen Formula in the Treatment of Diabetic Nephropathy.
- Source :
- Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy; Feb2024, Vol. 17, p739-757, 19p
- Publication Year :
- 2024
-
Abstract
- Objectives such as TP53, PTEN, AKT1, BCL2, BCL2L1, PINK-1, PARKIN, LC3B, and NFE2L2, along with various growth-inducing routes. Our findings demonstrated that TSF effectively repaired the structure of mitochondria in db/db mice. TSF greatly enhanced the mRNA levels of PINK-1. WB and IHC findings indicated that TSF had a notable impact on activating the PINK-1/PARKIN signaling pathway in db/db mice, significantly increasing LC3 and NRF2 expression. Conclusion: Our results indicate that TSF effectively addresses DN by activating the PINK-1/PARKIN signaling pathway and enhancing Mitochondrion structure in experimental diabetic nephropathy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11787007
- Volume :
- 17
- Database :
- Complementary Index
- Journal :
- Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 176809212
- Full Text :
- https://doi.org/10.2147/DMSO.S443352