Korea University Researchers Update Current Study Findings on Cancer (Depletion of proteasome subunit PSMD1 induces cancer cell death via protein ubiquitination and DNA damage, irrespective of p53 status).

A recent study conducted by researchers at Korea University has found that the depletion of the proteasome subunit PSMD1 can induce cell death in cancer cells through protein ubiquitination and DNA damage, regardless of the p53 status. PSMD1 is a subunit of the 19S regulatory particle in the 26S proteasome complex, and its depletion was found to cause cell cycle arrest, DNA damage, and apoptosis in cancer cells. These effects were not observed in normal cells. The findings suggest that PSMD1 could be a potential therapeutic target for hepatocellular carcinoma (HCC), a highly aggressive form of cancer. [Extracted from the article]