Patent Issued for Ion exchange membrane chromatography (USPTO 11945837).

A patent has been issued to Genentech Inc. for an ion exchange membrane chromatography method that enhances the efficiency of downstream chromatography steps for protein purification. The method involves passing a composition containing a polypeptide of interest and contaminants through an ion exchange membrane, collecting a fraction containing the polypeptide, subjecting the composition to further purification steps, and recovering the purified polypeptide. The method can be used for the purification of antibodies, antibody fragments, and polypeptides, and it offers an alternative to the commonly used Protein A chromatography method. The patent provides detailed information on the operating conditions and contaminants that can be targeted using this method. [Extracted from the article]