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Association of cardiometabolic multimorbidity with all-cause and cardiovascular disease mortality among Chinese hypertensive patients.
- Source :
- Journal of Geriatric Cardiology; Feb2024, Vol. 21 Issue 2, p211-218, 8p
- Publication Year :
- 2024
-
Abstract
- BACKGROUND Hypertension usually clusters with multiple comorbidities. However, the association between cardiometabolic multimorbidity (CMM) and mortality in hypertensive patients is unclear. This study aimed to investigate the association between CMM and all-cause and cardiovascular disease (CVD) mortality in Chinese patients with hypertension. METHODS The data used in this study were from the China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Risk Factors (CONSIDER), which comprised 5006 participants aged 19-91 years. CMM was defined as the presence of one or more of the following morbidities: diabetes mellitus, dyslipidemia, chronic kidney disease, coronary heart disease, and stroke. Cox proportional hazard models were used to calculate the hazard ratios (HR) with 95% CI to determine the association between the number of CMMs and both all-cause and CVD mortality. RESULTS Among 5006 participants [mean age: 58.6 ± 10.4 years, 50% women (2509 participants)], 76.4% of participants had at least one comorbidity. The mortality rate was 4.57, 4.76, 8.48, and 16.04 deaths per 1000 person-years in hypertensive patients without any comorbidity and with one, two, and three or more morbidities, respectively. In the fully adjusted model, hypertensive participants with two cardiometabolic diseases (HR = 1.52, 95% CI: 1.09-2.13) and those with three or more cardiometabolic diseases (HR = 2.44, 95% CI: 1.71-3.48) had a significantly elevated risk of all-cause mortality. The findings were similar for CVD mortality but with a greater increase in risk magnitude. CONCLUSIONS In this study, three-fourths of hypertensive patients had CMM. Clustering with two or more comorbidities was associated with a significant increase in the risk of all-cause and cardiovascular mortality among hypertensive patients, suggesting more intensive treatment and control in this high-risk patient group. [ABSTRACT FROM AUTHOR]
- Subjects :
- HYPERTENSION epidemiology
CARDIOVASCULAR disease related mortality
MORTALITY risk factors
RISK assessment
STATISTICAL correlation
PEARSON correlation (Statistics)
CARDIOVASCULAR diseases
HYPERLIPIDEMIA
CORONARY disease
RESEARCH funding
HYPERTENSION
KRUSKAL-Wallis Test
CARDIOVASCULAR diseases risk factors
PATIENT care
DESCRIPTIVE statistics
CHI-squared test
SURVEYS
LONGITUDINAL method
CHRONIC kidney failure
RESEARCH
STROKE
COMPARATIVE studies
CONFIDENCE intervals
DATA analysis software
COMORBIDITY
DIABETES
PROPORTIONAL hazards models
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 16715411
- Volume :
- 21
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Geriatric Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 176621018
- Full Text :
- https://doi.org/10.26599/1671-5411.2024.02.003