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Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI.
- Source :
- International Journal of Biomedical Imaging; 4/13/2024, Vol. 2024, p1-10, 10p
- Publication Year :
- 2024
-
Abstract
- Background. Ferumoxytol (Ferahame, AMAG Pharmaceuticals, Waltham, MA) is increasingly used off-label as an MR contrast agent due to its relaxivity and safety profiles. However, its potent T2 ∗ relaxivity limits achievable T1-weighted positive contrast and leads to artifacts in standard MRI protocols. Optimization of protocols for ferumoxytol deployment is necessary to realize its potential. Methods. We present first-in-human clinical results of the Quantitative Ultrashort Time-to-Echo Contrast Enhanced (QUTE-CE) MRA technique using the superparamagnetic iron oxide nanoparticle agent ferumoxytol for vascular imaging of the head/brain in 15 subjects at 3.0T. The QUTE-CE MRA method was implemented on a 3T scanner using a stack-of-spirals 3D Ultrashort Time-to-Echo sequence. Time-of-flight MRA and standard TE T1-weighted (T1w) images were also collected. For comparison, gadolinium-enhanced blood pool phase images were obtained retrospectively from clinical practice. Signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and intraluminal signal heterogeneity (ISH) were assessed and compared across approaches with Welch's two-sided t -test. Results. Fifteen volunteers (54 ± 17 years old, 9 women) participated. QUTE-CE MRA provided high-contrast snapshots of the arterial and venous networks with lower intraluminal heterogeneity. QUTE-CE demonstrated significantly higher SNR (1707 ± 226), blood-tissue CNR (1447 ± 189), and lower ISH (0.091 ± 0.031) compared to ferumoxytol T1-weighted (551 ± 171 ; 319 ± 144 ; 0.186 ± 0.066 , respectively) and time-of-flight (343 ± 104 ; 269 ± 82 ; 0.190 ± 0.016 , respectively), with p < 0.001 in each comparison. The high CNR increased the depth of vessel visualization. Vessel lumina were captured with lower heterogeneity. Conclusion. Quantitative Ultrashort Time-to-Echo Contrast-Enhanced MR angiography provides approximately 5-fold superior contrast with fewer artifacts compared to other contrast-enhanced vascular imaging techniques using ferumoxytol or gadolinium, and to noncontrast time-of-flight MR angiography, for clinical vascular imaging. This trial is registered with NCT03266848. [ABSTRACT FROM AUTHOR]
- Subjects :
- CEREBRAL angiography
IRON oxide nanoparticles
DIAGNOSTIC imaging
T-test (Statistics)
MEDICAL quality control
BRAIN
RADIOLOGIC technology
CHEMICAL elements
HEAD
RETROSPECTIVE studies
MAGNETIC resonance angiography
MEDICAL records
ACQUISITION of data
CORONARY angiography
COMPARATIVE studies
CONTRAST media
SENSITIVITY & specificity (Statistics)
Subjects
Details
- Language :
- English
- ISSN :
- 16874188
- Volume :
- 2024
- Database :
- Complementary Index
- Journal :
- International Journal of Biomedical Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 176578936
- Full Text :
- https://doi.org/10.1155/2024/9763364