New Research on Necroptosis from Department of Pathology Summarized (Dihydromyricetin regulates RIPK3-CaMKII to prevent necroptosis in high glucose-stimulated cardiomyocytes).

A recent study published in the journal Heliyon discusses the potential of dihydromyricetin (DHY), a compound extracted from Ampelopsis grossedentata, in preventing necroptosis in high glucose-stimulated cardiomyocytes. Necroptosis is a common cardiovascular complication associated with diabetic cardiomyopathy. The study found that DHY improved cell viability, enhanced ATP levels, and reduced LDH content in high glucose-stimulated cardiomyocytes, suggesting that it attenuates cell injury. DHY also decreased the expression of RIPK3 and cleaved-caspase 3, indicating its potential in alleviating necroptosis. Additionally, DHY reduced oxidative stress levels and inhibited CaMKII oxidation in high glucose-stimulated cardiomyocytes. The findings suggest that DHY may serve as a potential agent for preventing and treating diabetic cardiomyopathy. [Extracted from the article]