Studies from First Affiliated Hospital of Xi'an Jiaotong University Reveal New Findings on Gliomas (High expression of RTEL1 predicates worse progression in gliomas and promotes tumorigenesis through JNK/ELK1 cascade).

A recent study conducted at the First Affiliated Hospital of Xi'an Jiaotong University has found that high expression of the RTEL1 gene is associated with worse progression and promotes tumorigenesis in gliomas, which are the most common primary intracranial tumors worldwide. The researchers observed that RTEL1 expression is positively correlated with telomere length in glioma tissue and serves as a poor prognostic factor in certain patients. In vitro and in vivo studies also demonstrated that RTEL1 promotes the proliferation, migration, and invasion ability of glioma cells. The study suggests that RTEL1 may be a prognostic biomarker for gliomas and that it promotes tumorigenesis through the JNK/ELK1 cascade. [Extracted from the article]