Studies from Zhejiang University Further Understanding of Immunologic Receptors (Timp1 Protects Against Blood-brain Barrier Disruption After Subarachnoid Haemorrhage By Inhibiting Ubiquitination of Astrocytic B1-integrin).

A study conducted by researchers at Zhejiang University in China explores the role of tissue inhibitor of matrix metalloprotease-1 (TIMP1) in protecting the blood-brain barrier (BBB) after subarachnoid hemorrhage (SAH). The researchers found that TIMP1 is upregulated after SAH and its administration mitigates SAH-induced brain injury. TIMP1 is primarily expressed in astrocytes and its overexpression leads to increased expression of beta 1-integrin in astrocytes, preserving the attachment of astrocytic endfeet to the endothelium and maintaining the integrity of the BBB. The study suggests that TIMP1 inhibits the interaction between beta 1-integrin and Trim21 in astrocytes, rescuing the ubiquitination of astrocytic beta 1-integrin and ultimately mitigating SAH-induced brain injury. [Extracted from the article]