Research progress of microRN A-mediated immune function of CD4+T cells subsets in immune thrombocytopenia.

MicroRNA (miRNA) is a kind of small non-coding single stranded RNA that can participate in multiple biological processes. It also plays an important role in regulating the immune function of the body. Immune thrombocytopenia (ITP) is an autoimmune disease, whose cause and deterioration are closely related to miRNA regulates immune function of CD4⁺T cells subsets. In ITP patients, different expression of miRNA can affect the immune function of CD4⁺T cells subsets, which causes not only unbalanced expression of Th1/Th2, Th17/Treg and excessive differentiation of TFH, but also abnormal cytokine secretion furthermore. This paper summarizes the unbalanced mechanism of miRNA regulating immune function of CD4⁺T cells subsets in ITP, so as to provide inspiration for exploring the immunology and immunotherapy of ITP. [ABSTRACT FROM AUTHOR]