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Association of congenital heart disease and neurodevelopmental disorders: an observational and Mendelian randomization study.
- Source :
- Italian Journal of Pediatrics; 4/8/2024, Vol. 50 Issue 1, p1-11, 11p
- Publication Year :
- 2024
-
Abstract
- Background: This study aims to thoroughly study the connection between congenital heart disease (CHD) and neurodevelopmental disorders (NDDs) through observational and Mendelian randomization (MR) designs. Methods: This observational study uses data from the National Survey of Children's Health (2020–2021). Multivariable logistic regression and propensity score matching (PSM) were performed to analyze the association. PSM was used to minimize bias for covariates such as age, race, gender, maternal age, birth weight, concussion or brain injury, preterm birth, cerebral palsy, Down syndrome, and other inherited conditions. In MR analyses, inverse variance-weighted measures, weighted median, and MR-Egger were employed to calculate causal effects. Results: A total of 85,314 children aged 0–17 were analyzed in this study. In regression analysis, CHD (p = 0.04), the current heart condition (p = 0.03), and the severity of current heart condition (p < 0.05) had a suggestive association with speech or language disorders. The severity of current heart condition (p = 0.08) has a potential statistically significant association with attention deficit hyperactivity disorder(ADHD). In PSM samples, ADHD(p = 0.003), intellectual disability(p = 0.012), and speech or language disorders(p < 0.001) were all significantly associated with CHD. The severity of current heart condition (p < 0.001) also had a significant association with autism. MR analysis did not find causality between genetically proxied congenital cardiac malformations and the risk of NDDs. Conclusions: Our study shows that children with CHD have an increased risk of developing NDDs. Heart conditions currently and severity of current heart conditions were also significantly associated with these NDDs. In the future, we need to try more methods to clarify the causal relationship between CHD and NDDs. [ABSTRACT FROM AUTHOR]
- Subjects :
- AUTISM risk factors
CONGENITAL heart disease
RISK assessment
DISABILITIES
CHILD psychopathology
DOWN syndrome
ATTENTION-deficit hyperactivity disorder
GENOME-wide association studies
T-test (Statistics)
RESEARCH funding
SCIENTIFIC observation
MULTIPLE regression analysis
SEX distribution
PREMATURE infants
QUESTIONNAIRES
STATISTICAL sampling
FISHER exact test
LOGISTIC regression analysis
DESCRIPTIVE statistics
AGE distribution
CEREBRAL palsy
CHI-squared test
RACE
INTELLECTUAL disabilities
ODDS ratio
LANGUAGE disorders
BIRTH weight
BRAIN injuries
SPEECH disorders
CONFIDENCE intervals
DATA analysis software
BRAIN concussion
DISEASE risk factors
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 17208424
- Volume :
- 50
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Italian Journal of Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 176498123
- Full Text :
- https://doi.org/10.1186/s13052-024-01610-3