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Alcohol and drug use severity are independently associated with antiretroviral adherence in the current treatment era.
- Source :
- AIDS Care; May2024, Vol. 36 Issue 5, p618-630, 13p
- Publication Year :
- 2024
-
Abstract
- Substance use in people with HIV (PWH) negatively impacts antiretroviral therapy (ART) adherence. However, less is known about this in the current treatment era and the impact of specific substances or severity of substance use. We examined the associations of alcohol, marijuana, and illicit drug use (methamphetamine/crystal, cocaine/crack, illicit opioids/heroin) and their severity of use with adherence using multivariable linear regression in adult PWH in care between 2016 and 2020 at 8 sites across the US. PWH completed assessments of alcohol use severity (AUDIT-C), drug use severity (modified ASSIST), and ART adherence (visual analogue scale). Among 9400 PWH, 16% reported current hazardous alcohol use, 31% current marijuana use, and 15% current use of ≥1 illicit drugs. In multivariable analysis, current methamphetamine/crystal use, particularly common among men who had sex with men, was associated with 10.1% lower mean ART adherence (p < 0.001) and 2.6% lower adherence per 5-point higher severity of use (ASSIST score) (p < 0.001). Current and more severe use of alcohol, marijuana, and other illicit drugs were also associated with lower adherence in a dose-dependent manner. In the current HIV treatment era, individualized substance use treatment, especially for methamphetamine/crystal, and ART adherence should be prioritized. [ABSTRACT FROM AUTHOR]
- Subjects :
- CLINICAL drug trials
HIV infection transmission
SUBSTANCE abuse
PATIENT compliance
SELF-evaluation
STATISTICAL models
ANTIRETROVIRAL agents
METHAMPHETAMINE
ACADEMIC medical centers
VIRAL load
RESEARCH funding
MULTIPLE regression analysis
QUESTIONNAIRES
VISUAL analog scale
CD4 lymphocyte count
SEVERITY of illness index
HIV infections
MULTIVARIATE analysis
DESCRIPTIVE statistics
RELATIVE medical risk
PSYCHOLOGY of HIV-positive persons
HEROIN
MEN who have sex with men
RESEARCH
CANNABIS (Genus)
ALCOHOLISM
INDIVIDUALIZED medicine
HEALTH outcome assessment
COMPARATIVE studies
DISEASE susceptibility
INFECTIOUS disease transmission
CONFIDENCE intervals
DRUGS of abuse
CRACK cocaine
REGRESSION analysis
EVALUATION
DISEASE risk factors
ADULTS
Subjects
Details
- Language :
- English
- ISSN :
- 09540121
- Volume :
- 36
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- AIDS Care
- Publication Type :
- Academic Journal
- Accession number :
- 176475467
- Full Text :
- https://doi.org/10.1080/09540121.2023.2223899