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2‐Hydroxyethyl methacrylate (2‐HEMA) sensitization, a global epidemic at its peak in Spain?

Authors :
Gatica‐Ortega, Maria Elena
Pastor‐Nieto, Maria Antonia
Giménez‐Arnau, Ana María
Mercader‐García, Pedro
Sanz‐Sánchez, Tatiana
Carrascosa‐Carrillo, José Manuel
Córdoba‐Guijarro, Susana
Sánchez‐Pérez, Javier
Silvestre, Juan Francisco
Frutos, Francisco Javier Ortiz‐de
Tous‐Romero, Fátima
Fernández‐Redondo, Virginia
Serra‐Baldrich, Esther
Ruíz‐González, Inmaculada
González Pérez, Ricardo
Miquel‐Miquel, Javier
Guillén, Paloma Sánchez‐Pedreño
Hervella‐García, Marcos
Heras‐Mendaza, Felipe
Gómez‐de‐la‐Fuente, Enrique
Source :
Contact Dermatitis (01051873); May2024, Vol. 90 Issue 5, p507-513, 7p
Publication Year :
2024

Abstract

Background: A global epidemic of allergic contact dermatitis to (meth)acrylates has been described in relation to the widespread use of manicure products. Objectives: To evaluate the frequency of sensitization to 2‐hydroxyethyl methacrylate (2‐HEMA) among consecutively patch tested patients with eczema in Spain; the percentage of current relevance; the MOAHLFA index; and, the potential sources of exposure to (meth)acrylates. Methods: From January 2019 to December 2022, 2‐HEMA 2% pet. was prospectively patch tested in 24 REIDAC (Spanish Allergic Contact Dermatitis Registry) centres. Results: Six thousand one hundred thirty‐four patients were consecutively patch tested with 2‐HEMA 2% pet. 265/6134 (4.3%) were positive. Positive reactions of current relevance were identified to involve 184/265 (69%). The efficiency (number of patch tests needed to detect relevant positive patch test reactions) was 34 (6134/184). The variable 'occupational' was found to be significantly associated with a higher risk for relevant positive reactions to 2‐HEMA (OR: 10.9; 95% CI: 8.1–14.9). Conclusion: (Meth)acrylate sensitization is a prevalent health issue in Spain. 2‐HEMA 2% pet. has been identified to be a highly effective (meth)acrylate allergy marker in the GEIDAC baseline series. The responsible authorities should implement policies guaranteeing accurate labelling of industrial, medical, and consumer materials while ensuring the enforcement of said labelling through appropriate legal means. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01051873
Volume :
90
Issue :
5
Database :
Complementary Index
Journal :
Contact Dermatitis (01051873)
Publication Type :
Academic Journal
Accession number :
176474289
Full Text :
https://doi.org/10.1111/cod.14520