Research on Tissue Engineering Published by Researchers at Third Military Medical University (Construction of tissue-engineered vascular grafts with enhanced patency by integrating heparin, cell-adhesive peptide, and carbon monoxide...).

A recent study conducted by researchers at Third Military Medical University explores the use of small-diameter tissue-engineered vascular grafts (sdTEVGs) as a potential treatment for vascular bypass grafting and replacement therapy. The study focuses on addressing complications such as intimal hyperplasia and thrombosis that can impair graft patency during transplantation. The researchers developed a multifunctional surface on the TEVGs using a covalent-organic framework (COF)-based carbon monoxide (CO) nanogenerator, LXW-7 peptide, and heparin. This approach successfully prevented thrombosis and stenosis, promoted endothelialization, and suppressed inflammation, resulting in improved graft patency. The study provides a novel approach for constructing antithrombotic and anti-hyperplastic TEVGs. [Extracted from the article]