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Theta-frequency medial septal nucleus deep brain stimulation increases neurovascular activity in MK-801-treated mice.

Authors :
Crown, Lindsey M.
Agyeman, Kofi A.
Wooseong Choi
Zepeda, Nancy
Iseri, Ege
Pahlavan, Pooyan
Siegel, Steven J.
Charles Liu
Christopoulos, Vasileios
Lee, Darrin J.
Source :
Frontiers in Neuroscience; 2024, p1-12, 12p
Publication Year :
2024

Abstract

Introduction: Deep brain stimulation (DBS) has shown remarkable success treating neurological and psychiatric disorders including Parkinson's disease, essential tremor, dystonia, epilepsy, and obsessive-compulsive disorder. DBS is now being explored to improve cognitive and functional outcomes in other psychiatric conditions, such as those characterized by reduced N-methyl-Daspartate (NMDA) function (i.e., schizophrenia). While DBS for movement disorders generally involves high-frequency (>100 Hz) stimulation, there is evidence that low-frequency stimulation may have beneficial and persisting effects when applied to cognitive brain networks. Methods: In this study, we utilize a novel technology, functional ultrasound imaging (fUSI), to characterize the cerebrovascular impact of medial septal nucleus (MSN) DBS under conditions of NMDA antagonism (pharmacologically using Dizocilpine [MK-801]) in anesthetized male mice. Results: Imaging from a sagittal plane across a variety of brain regions within and outside of the septohippocampal circuit, we find that MSN theta-frequency (7.7 Hz) DBS increases hippocampal cerebral blood volume (CBV) during and after stimulation. This effect was not present using standard high-frequency stimulation parameters [i.e., gamma (100 Hz)]. Discussion: These results indicate the MSN DBS increases circuit-specific hippocampal neurovascular activity in a frequency-dependent manner and does so in a way that continues beyond the period of electrical stimulation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16624548
Database :
Complementary Index
Journal :
Frontiers in Neuroscience
Publication Type :
Academic Journal
Accession number :
176378554
Full Text :
https://doi.org/10.3389/fnins.2024.1372315