اثرات آرامبخشی گیاه دارویی سنبلالطیب.

Introduction: Valerian, scientifically known as Valeriana officinalis, is a herbaceous plant with numerous medicinal properties. Its root serves as a painkiller and antispasmodic, containing valeric acid that has anti-musclecontraction properties. Valerian has various medical uses, such as sedative, hypnotic, anti-anxiety, anti-spasmodic, antidepressant, anti-hysteric, anti-hypertensive, and diuretic effects. For this reason, valerian has been introduced by the Food and Drug Administration (FDA) as a food supplement to reduce anxiety. The purpose of this study is to investigate the sedative effect of the valerian plant. Methods and Materials: This review was conducted by searching the keywords valerian, catnip, and sedation through journal database platforms such as Google Scholar, Pubmed, and ScienceDirect as search engines for journals related to this article between 2001 and 2023. 37 articles were studied, and after removing articles that did not match the purpose of this research and duplicates, a total of 21 articles were used in this research. Result: The research showed that this plant is known as an agonist of gamma-aminobutyric GABA receptors. Studies also show that this plant inhibits valeric acid, the enzyme responsible for GABA catabolism, and increases the concentration of GABA in the brain, reduces the activity of different brain nuclei, and causes sedative effects. Also, the property of this plant is similar to benzodiazepines and barbiturates. Conclusion: According to the attained results, natural materials are superior to synthetic drugs due to fewer side effects and no alterations in the physiological and biochemical pathways, so it is suggested to conduct more comprehensive research in this area. [ABSTRACT FROM AUTHOR]